Skip to end to find major games to pick up

If you're into RPG's I'd definately pick up Folklore, and I guess if you're a fan of Final Fantasy maybe the new FF when it comes out in America. Heavenly Sword is pretty awesome, it's like a God of War clone except you fight hundreds of enemies at once sometimes, and you're a chick. Like IceWarm said, MGS4 is a must for PS3. The Skate series is pretty good although it isn't PS3 exclusive. Burnout Paradise is a pretty awesome Multiplatform game and the full game can be bought off the PSN. Ninja Gaiden Sigma might be good if you want a rehash of a game. PixelJunk Monsters I've heard is great, it's a tower defense game in vein of such games as Desktop Tower defence. Everyday Shooter is pretty interesting to say the least, it's a game that has the elements of a shmup, rhythm game, and a puzzle game and it's pretty good. GT5: Prolouge is a must for racing fans, Warhawk isn't my cup of tea, but it is pretty good, and it's not a FPS it's a few different types of games mixed with eachother like Everyday Shooter. Tekken 5 is always a bit of fun, especially the multiplayer, TES IV: GOTY Edition is pretty epic in scale, probably a 200+ hour experience if you do everything. Super Stardust HD is also a pretty good game and I'd definately give it a try. Assassin's Creed and Assassin's Creed 2 when it comes out, 1st one was awesome and you might have beat it, but I'd still pick it up anyway. Not sure if you'd really like Resistance 1 and 2 because they are FPS's but they've got a good story and good online. I'd pick up at least Motorstorm 1, it's a pretty good racing game but I don't think there's multiplayer, although the sequels might have added that in. The Orange Box is always good fun. I'd give the new Ratchet & Clank games a try although I've never played them, I heard they were good compared to the older games. Uncharted is like the fucking must buy game for PS3 other than MGS4, it's just epicly awesome. Freakin pick it up. GTA IV if that's your cup of tea. Army of Two is pretty good, once again, not my cup of tea, but it's pretty good. Devil May Cry 4 I thought was pretty interesting with fun gameplay and everything. Lair I'd check out as a rental because it could be beaten in a weekend at least, I'd check out Mercenaries 2 as well with it being a pretty good game in my opinion. You might not like the game but not knowing I reccommend Mirror's Edge, liking it a lot more than most people did, it had interesting mechanics, fun gameplay, and a sub-par story at least. Call of Jaurez and it's sequel Bound In Blood if you wanna rent those or something, I never really liked them. Once again, another freakin awesome game is Valkyria Chronicles, a strategy RPG that I absolutely love. Civilization Revolution is pretty good. Condemned 2: Bloodshot is good although I never beat it because I never complete horror games. InFamous and Prototype are pretty awesome and I'd definately at least pick them up as rentals because they're just pretty awesome. Red Faction Guerilla is pretty good, and that's about all I've got to reccommend.

Major games to play
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MGS4
Heavenly Sword
Uncharted: Drake's Fortune
Valkyria Chronicles
Burnout Paradise
GT5: Prolouge
TES IV: GOTY Edition
Everyday Shooter
Folklore
FF13 or whatever if you like new FF games.