I'm disappointed by the lack of one the most bizarre lines in Star Fox 64 if you use it out of context:
"So Andross, you show your true form!"
I have said that line to many a confused listener.
Nothing beats the original RE for unintentional lines, by the way.
"Its not just a poisonous snake, its a monster!"
"This house is too dangerous, there are terrible demons(?), OUCH..."
Jill: There's a page missing!
Barry: Yeah, I've thought about that too. Perhaps that was the most important part.
Wesker: Now Jill, can you go?
Barry: I'm going with you, Chris is our old partner, you know?
Of course several other lines were god-awful for acting alone, as this website greatly demonstrates.
http://www.audioatrocities.com/games/residentevil/index.html