You can replace the PS3 harddrive with almost any 2.5" SATA hard drive, which are mostly used for Laptops.
There is a growing database of which models works. Most due, only some off brands do not have the power connector and sata connector lined up right.
I have also heard that the default PS3s use 5400RPM drives, and if you replace them with 7200RPM drives, you'll notice better load times.
They are also really easy to replace:
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